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SSRIs suck. Withdrawal sucks even more.

By Quantumpanda in Quantumpanda's Diary
Wed Jun 11, 2003 at 06:14:48 PM EST
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[Note: this was originally posted to my blog on Monday. I figured that adding it to my diary here would be a good idea. I'll be copying the more interesting of my blog entries to my diary here from time to time.]

If anyone out there reading this is getting a recommendation from a mental health professional for SSRIs for depression (Prozac, Zoloft, Paxil, Celexa, Lexapro), especially Celexa or Lexapro, think about this before you accept it.


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For some people (people like me), taking a drug like Celexa is a no-win situation. It numbs my emotional responses, so that while I don't feel as bad when I feel bad, I also don't feel as good when I feel good. Not what I want out of my psychotropics.

Worse than that, all SSRIs, just like the older tricyclic antidepressants, have the far too common side effect of reducing sex drive and sexual ability. That may not seem bad when you hear about it, but trust me: having a healthy sex life is important to physical and mental health. Would you rather be depressed because you're not taking a drug to fix it, or because you want to have sex and can't get anywhere with it?

But worst of all: I recommend 100% against taking any SSRI if you believe it's not going to be long term. See, for many of us, SSRIs induce a mild chemical dependency (I think it primarily has to do with dependence on increased serotonin levels). So when you stop taking it, you have withdrawal.

I'm in the middle of weathering a withdrawal right now. Hopefully, this will be the last time, but I can't say for certain. Every time I've gone off an SSRI, I've told myself that I'm not putting myself through that again. This is now the third time I've been on and then off of one (Lexapro this time).

So, you may be asking, what's SSRI/serotonin withdrawal like? Ick. The first few days are easy, because your body takes a few days to flush out all of the drug. Somewhere around the fifth or sixth day after you stop taking it, the symptoms start. Withdrawal symptoms may vary, but for me, it's like continual motion sickness that lasts for days, mixed with a mild migraine headache. It generally doesn't reach the point of actually vomiting, but the combination of headache, dizziness, and nausea makes me wish I could vomit it out so I could feel better. I can't, of course, because the problem isn't the presence of a toxin but rather the absence of one my body had gotten used to.

What I do to try to relieve the symptoms is pretty simple. I've found that, for me, Dramamine and Tylenol help take the edge off the dizziness and headache. Treating it like a migraine in terms of my behavior helps also (that's just behavior...migraine medications won't help this). And since part of the problem is the reduced serotonin levels after stopping the drug that kept them elevated, and some studies suggest that serotonin and blood sugar are linked, I've also found that keeping my blood sugar up and plenty of food in my stomach helps the nausea. That is, if I can get past the nausea long enough to feel like eating something.

But in the end, none of this stuff helps much during the peak of the symptoms, which is generally days seven through ten after the last dose. (Today is day ten for me this round.) During that stretch, all I can stomach doing is laying on the couch. Which is about all I've done for the last few days.

One thing seems to help during the peak period: adrenaline. I had a minor panic attack on Saturday morning, and so most of the day Saturday I felt okay with the withdrawal symptoms. I thought maybe the withdrawal was going to be shorter this time. But the respite was illusory. I made the mistake of going out on a preplanned excursion with a group of friends to the dollar theater for a re-viewing of The Two Towers. We were planning to MSTify it, so we all sat in the front row to avoid bothering other patrons. (We try to be polite when we're being rude.)

Ugh. BIG mistake. The jerky hand-held camera movements through many sequences made me as nauseated as I got when I first watched The Blair Witch Project. I kept having to close my eyes every few minutes to quell the nausea. Good thing I had seen the movie before.

And then, when the movie was over, the scrolling credits made me even queasier. I had to quickly urge our merry band of mischief makers out to the parking lot so I didn't pass out on the spot.

I'm hoping that since this is day ten, tomorrow will be better. But at this point, I'm not holding my breath for it. I suspect that tomorrow will find me exactly where today did: flat on my back on the couch with my laptop next to me. Not where I want to be. (As nice as it would seem to be to be able to lay on the couch all day and websurf, it's not much fun when the heat from the laptop is making you more nauseated. And, even though I hate my employer, at this point I would still much rather be at work than be feeling the way I do right now.)

So keep all that in mind when your doctor recommends an SSRI. You might consider trying Wellbutrin instead; it doesn't have the sexual or numbing side effects, and I've never experienced any withdrawal effects from it.

[Follow-up note: this was written two days ago, at the peak of my withdrawal. Today, I only notice the symptoms at all if I stand up for too long or move too suddenly. I did spend day eleven at home, but I didn't have to stay flat on my back. So, even though the withdrawal is nasty, it does have an end to it.]

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SSRIs suck. Withdrawal sucks even more. | 11 comments (11 topical, editorial, 0 hidden)
Yeah (long-winded) (5.00 / 1) (#1)
by jew on Wed Jun 11, 2003 at 06:40:06 PM EST

I've been on 50-60 mg Paxil for about 14 months, I finally quit it for good. I've never had severe withdrawal symptoms, just itching all over my body that was kind of bad the first month off it.

I think you hit the nail right on the head with this entry. IMO, SSRIs are good for two scenarios: when you are going through an episode of severe depression and/or anxiety, and need to break out of it (even this can take numerous weeks or months, and SSRIs are only one factor in helping), or when you believe or know that you have a chemical imbalance and it would be your best option.

For the vast majority of us experiencing depression and anxiety, there is no chemical imbalance to blame. It is simply natural human emotion taken to an extreme, and it will pass. You can do things to help it along, including distancing yourself from the stressor(s), undergoing various forms of therapy, or using meditation. No need to introduce psychoactive drugs.

I have found that SSRIs do not help my mood significantly over the long-term. I can feel both good and depressed both on and off the medication. The only solidly evidenced effects were inhibition numbing of emotions (ever been diagnosed with depression and medicated? quit the meds and youll experience the feelings that constitute depression), tremendous weight gain (40 pounds in my case), and sexual dysfunction (delayed orgasm can arguably be a good thing in some cases, however).

I find it quite hypocritical when psychiatric establishments get their patients who've been on street drugs off one type of drug and attempt to indocrinate them of all the dangers of these drugs, whilst loading them up with, and in some cases punishing those who won't take, pharmeceuticals. They are both undeniably psychoactive drugs that operate to change levels of mood-enhancing chemicals. Neither is specifically for that purpose. Hell, the psychiatric establishment doesn't know what causes depression -- "Depression may be caused by an imbalance of chemicals in your brain" (psychlogical literature I've read states this is the case less than 10% of the time) -- but they are all too quick to hand out a mood-lifting drug as a cure-all and feed the massive, multi-billion dollar pharmeceutical industry, and declare you a 'good patient' for taking them and not causing any trouble -- as if that's any different from sitting around smoking weed.

Just yesterday, I went to my psychiatrist just to keep on my dad's good side, and get my prescriptions. Of course, I could have had a debate or argument with her about the merits of the Medical Model of Mental Illness, but nope, I just stuck with my story/lie, I've been taking my meds. She could tell I was lying though, and got kind of smart with me, and probably thought I was still doing drugs too -- brought up my history of substance abuse and cautiously mentioned 'coke' -- no. I used to smoke pot, you are lumping these drugs together as evil, assuming I have done all of them and am hiding it from you. While all you advocate, and advocate strongly, for my cause is taking drugs, so. 'Course I didn't tell her that, and who knows what she wrote on my file, but I'll not tell her I've stopped, I've had that sort of thing come back to bite me in the ass more than once.

So yeah, now the only drug I've got to knock out is nicotine. Three cheers for being in an uninhibited, natural state of mind!
--
jew

The other side of the coin (5.00 / 1) (#2)
by LilDebbie on Wed Jun 11, 2003 at 07:20:36 PM EST

I understand that my situation is significantly different from yours in that my meds achieve quite the opposite affect of yours, but I thought I'd chip in on my experience with phenytoin (trade name Dilantin), a serotonin antogonist.

The first thing I noticed is a lack of depression for a drug that should be causing it. Of course, it's entirely possible that my depression has nothing to do with chemical imbalances so lowering my serotonin levels shouldn't aggravate it. Other than that, I've had little to no problem with it (except that I have to limit my drinking somewhat, and by limit I mean no more than six drinks a night). I think people like yourself have problems with SSRIs because you don't have a chemical balance and said drugs only bring you further from your proper levels. Anyone, just my $0.02.

Oh yeah, my chemical imbalance is that sometimes my brain becomes TOO active and I writhe uncontrollably on the floor for 5-10 minutes. Chee!

My name is LilDebbie and I have a garden.
- hugin -

been there... (5.00 / 1) (#3)
by MrClaws on Wed Jun 11, 2003 at 07:35:26 PM EST

I quit 60mg of Paxil, 2mg Risperdal and 250mg of Luvox cold turkey and man did it suck. I mainly suffered from the brain zaps, where it feels like a light shock through out the body. The whole thing lasted around 3 weeks and I just had to do something where my eyes wouldn't be moving around a lot, that ause the brain zaps. I had a good time on the drugs at about 4 months into taking the Paxil and Risperdal after that 4 months it all went down hill. I slept all day, I couldn't concentrate etc.. I can't say that I am against these drugs or any drugs for that matter they do help sometimes if you really have no clue as to what the fuck is going on with your brain. In my case, I had no idea what was going on and I fucking terrified. I went to a crisis center, had a 5 hospital stay and was put on the Paxil and Risperdal.

The doctors tell me I have OCD and from the way I act and think I will have to concur. I just hate it when I obsess about something negative. :)

Prozac. (5.00 / 1) (#4)
by V on Wed Jun 11, 2003 at 07:53:40 PM EST

I stopped 60 mg prozac two days ago. I just forgot to take it, forgot my appoinment and I will run out of it in a few days so I haven't bothered taking it again. I also took risperdal for a while but only made me sleepy. Right now I can't concentrate on anything and I don't really know if I have depression at all. Sometimes everything just sucks and some other times my mind just feels numb.

Anyway, I'll se if I have any withdrawal effects soon.

V.
---
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"well look up little troll" cts.
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"goodness gracious you're an idiot" mariahkillschickens

Antidepressents (5.00 / 2) (#5)
by Goatmaster on Wed Jun 11, 2003 at 08:34:39 PM EST

Are for the weak.  There's nothing they can do that a little sex, booze and fun can't cure.   Besides, the pharmacorps are just trying to get you hooked so they can hawk you more of their overpriced addictive poison.


... and so the Goatmaster has spoken
Reply from someone who's been there (5.00 / 1) (#6)
by Kasreyn on Wed Jun 11, 2003 at 10:33:49 PM EST

I've been on Celexa for chronic depression, went off cold turkey when I ran out of money to get more (it seems there is no generic), and am probably going back on it soon.

My withdrawal symptoms were not physical, like yours. It helped me sleep, so without it I had a harder time sleeping for a while. Mostly, I just had a really bad few weeks of depression. You know, feelings of worthlessness (more than usual, that is), wanting to just stop eating/sleeping until death arrived, etc. Got over it, as always.

I haven't had many bad experiences with Celexa, though it seems to give me the runs and dry mouth, a no-fun combination. I've not noticed it muffling my good feelings, though I've found I never have a panic attack while on it. That alone is enough reason to take it, IMO. I'm normally somewhat stoic, and it's normally next to impossible to get a tear out of me, but a panic attack can make me sob like a baby at the frustration and misery it induces. There's nothing worse in the world. I would rather puke than have a panic attack, and I hate puking more than anything else, by a LONG shot. If an expensive little pill can prevent my panic attacks, sign me the fuck up.


-Kasreyn


"Extenuating circumstance to be mentioned on Judgement Day:
We never asked to be born in the first place."

R.I.P. Kurt. You will be missed.
SSRIs suck. Withdrawal sucks even more. | 11 comments (11 topical, 0 editorial, 0 hidden)
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